学习经历、社会兼职及获奖情况

(1) 2016-09 至 2021-06, 吉林大学 动物医学学院 基础兽医学系 硕博连读 获博士学位

(2) 2011-09 至 2016-07, 吉林大学 动物医学学院 动物医学专业 获学士学位

主要研究成果以在第一作者或通讯作者在《EBioMedicine》、《Journal of Infection》、《Communications Biology》、《PHYTOmedicine》、《Journal of Agricultural and Food Chemistry》和《Biomedicine & Pharmacotherapy》等国际知名期刊上发表研究论文20余篇，获国家授权发明专利9项，美国专利1项。作为主要完成人获得国家新兽药证书1个；指导本科生获自治区级和校级大学生创新项目各1项；担任中国畜牧兽医学会兽医药理毒理学分会理事，兼任molecular和Front. Vet. Sci.等期刊审稿人。

研究领域

主要从事分子药理与毒理学研究，以病原菌毒力因子和耐药酶为靶标，在天然化合物或商品化药物活性成分中开展毒力因子或耐药酶抑制剂的筛选，并验证其抑制病原菌致病力和耐药性的作用及机制，为抗耐药病原菌感染提供了新的治疗策略和先导化合物。

代表性研究成果

1.Zhou Y,Wang J, Guo Y, Liu X, Liu S, Niu X, Wang Y, Deng X. Discovery of a potential MCR-1 inhibitor that reverses polymyxin activity against clinicalmcr-1-positive Enterobacteriaceae.Journal of Infection. 2019 May;78(5):364-372.

2.Xu L,Zhou Y, Niu S, Liu Z, Zou Y, Yang Y, Feng H, Liu D, Niu X, Deng X, Wang Y, Wang J. A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria.EBioMedicine. 2022 Apr;78:103943.

3.Zhou Y, Liu B, Chu X, Su J, Xu L, Li L, Deng X, Li D, Lv Q, Wang J. Commercialized artemisinin derivatives combined with colistin protect against critical Gram-negative bacterial infection,Communications Biology, 2022 Sep 8;5(1):931.

4.Zhou Y, Liu S, Wang T, Li H, Tang S, Wang J, Wang Y, Deng X. Pterostilbene, a Potential MCR-1 Inhibitor That Enhances the Efficacy of Polymyxin B.Antimicrobial Agents and Chemotherapy. 2018 Mar 27;62(4):e02146-17.

5.Lv H, Zhu Z, Qian C, Li T, Han Z, Zhang W, Si X, Wang J, Deng X, Li L, Fang T, Xia J, Wu S,Zhou Y. Discovery of isatin-β-methyldithiocarbazate derivatives as New Delhi metallo- β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates.Biomedicine&Pharmacotherapy. 2023 Oct;166:115439.

6.Sheng Q, Hou X, Wang Y, Wang N, Deng X, Wen Z, Li D, Li L,Zhou Y,Wang J. Naringenin Microsphere as a Novel Adjuvant Reverses Colistin Resistance via Various Strategies against Multidrug-Resistant Klebsiella pneumoniae Infection.Journal of Agricultural and Food Chemistry. 2022 Dec 19.

7.Lv H,Zhou Y, Liu B, Guan J, Zhang P, Deng X, Li D, Wang J. Polyphosphate Kinase Is Required for the Processes of Virulence and Persistence in Acinetobacter baumannii.Microbiology Spectrum. 2022 Jul 5:e0123022.

8.Song G,Zhou Y, Niu S, Deng X, Qiu J, Li L, Wang J. Nordihydroguaiaretic acid reverses the antibacterial activity of colistin against MCR-1-positive bacteria in vivo/in vitro by inhibiting MCR-1 activity and injuring the bacterial cell membrane.Phytomedicine. 2022 Jan 29;98:153946.

9.Xu L,Zhou Y, Xu J, Xu X, Lu G, Lv Q, Wei L, Deng X, Shen X, Feng H, Wang J. Anti-inflammatory, antioxidant and anti-virulence roles of atractylodin in attenuating Listeria monocytogenes infection.Frontiers in Immunology. 2022 Oct 28;13:977051.

10.Zhou Y, Wang T, Guo Y, Liu S, Wang J, Shen Y, Tang S, Wang Y, Deng X. In Vitro/Vivo Activity of Potential MCR-1 Inhibitor in Combination With Colistin Againsts mcr-1-Positive Klebsiella pneumonia.Frontiers in Microbiology. 2018 Jul 17;9:1615.